Ask the store to buy 22 ammo when you buy the gun, some have a stash in the back only sold with gun purchase. Plead with the guy at the counter to buy as much as you can, remind him it is for the misses as well
Welcome. Getting wife a small gun is a common misconception - while getting something with the grip that is not too large is important, more mass always equals less recoil. Try to take her with you when you go pickin
I hear very good feedback on S&W M&P .22, although do not own one myself.
Agree with folks above, Glocks are not for everybody. My hand hurts after 30 minutes with a CO2 Laser firing Glock at Gander Mountain virtual range, but I feel just fine after a two hour session with a real 1911...