If you are going with an AR10 platform why not just use a well designed factory cartridge in .308 Win. using monolithic bullets to maximize penetration as a baseline for comparison to either your own hand-loads or any of the other cartridge choices mentioned previously to decide if it's worth the investment in a new upper and reloading components?
Example:
http://www.hornady.com/store/308-Win-16 ... rformance/Velocity (fps) / Energy (ft-lbs)
MUZZLE | 100 | 200 | 300 | 400 | 500
2750/2770 | 2549/2380 | 2357/2035 | 2173/1730 | 1998/1462 | 1831/1228
.. Or you could pick up an inexpensive 30-06 and pair it with the 180 grain GMX Superperformance ammunition:
2820/3178 | 2632/2768 | 2451/2401