Nope - the other people were indeed right, that I wouldn't own any stinking little 45 caliber poodle shooter handgun, even if it did weigh 5 lbs. The primary reason I wouldn't own one is that I don't hunt, and why kill paper with a 45 when you can do it with a 50?? IF I hunted, that would be a whole different story, and with a scope you could kill most anything with this gun out to 200 yards and hardly have to worry about bullet drop. (Yes, you'd have to THINK about it, but it wouldn't be a show stopper like trying the same trick with a DE50.)
The primary rap against this gun is the heat and pressure of the escaping gases between the cylinder and the forcing cone, and on the original guns the throats eroded VERY fast. They went to micropolishing the throats to try and deal with this, but if the erosion on my Smith 500 barrel is any indication, sooner or later the throat on a 460 WILL erode. Micropolishing essentially only delays the inevitable, and seeing as I like to shoot a lot and only kill paper, I have no reason to own a 460. If you wanted to hunt with it (deer, black bears, moose, elk, wild boars, etc.) and not do much else, I'm sure it would be a fine gun. If you were only going to hunt with it, you could afford a box of factory ammo or two to get the gun sighted in. If you shoot more than that, you would go broke UNLESS you handload. Smith 500 ammo is $2.25 PER ROUND

, (and I think the 460 ammo is even MORE expensive...) but handloads with Ranier bullets only cost me about a quarter apiece. If you don't handload and shoot a 460 a lot, the ammo cost WILL eat you alive.
Ballistically, it's a lot flatter shooting gun than a 500, although with really hot Smith 500 loads the velocity gap is only 300 FPS, because you can get .500" 300 grain Gold Dots going 2,000 FPS with a Smith 500 if you want to. As far as terminal ballistics, nothing can challenge a .500" hollowpoint bullet. The other cool thing about the 460 is that Hornady went to the trouble of making a high ballistic coefficient bullet for the 460 round (it's a red ballistic tip), so that the retained energy at longer distances will be better.