Ah, the big bore stuff!! I love it!
I have a DE50, 500 mag in 4" and 8" and a 460 which I just got. The key to these calibers IMHO is to RELOAD!! Can't really load the 50AE down, so 34gr of H110 with a 300gr pill is what it gets, and it's fun to shoot. Recoil is there, but nothing outrageous. Not an all day range gun, but manageable.
I load pansy loads of 10gr Trail Boss with a 330gr lead pill i the 500. Shoots like a cap gun. Fun. I reload in the mid range and they're quite a bit more stout but still OK. I have some Corbon 440gr rounds that are quite powerful and not for the faint of heart or hand.
I just got a slug of stuff for the 460. Brass for 45 Colt, 454 Casull and 460 mag along with dies and bullets. In fact that is this weekend's project, to get some of those loaded.
If anyone ever wants to shoot any of these, let me know.
The DE50 with 10: bbl:

The 460:

The 500:
