6" S&W 617 paired with a twin 686+ were my first ever firearms purchase, and 25 years later still two of my favorites. I love the speed beez setup for the 617 with 100 rounds in a closeable loading box setup with a speed loader that will grab 10 at a time out of the box.
The 617 is great for new shooters to start with since it has no recoil to speak of, they can graduate into the 686 with 38s, then on to 357. 617 also seems to have a lot of aftermarket, had no trouble getting a fiber optic front sight, and I know I can swap the rear sight assembly with my 686 so that should mean tons of options.
Edit: The S&W 317 is the .22 revolver I have wanted for a while, but have never been able to do the mental gymnastics to justify buying one. Yet.
http://www.gunblast.com/SW_317.htm