I had a student on Saturday with small hands. The distance between his thumb and first finger joints is about the same as that between my last two finger joints (not much) and his fingers are very short. For comparison, his hands fit my LCP just fine though the LCP was too short in the grip.
He was shooting a NIB Glock 19 he bought at Gander mountain and had to radically change hand position to go from poor trigger placement to marginal magazine release placement.
Even with that, he shot a good target

but the Glock was pointed right into his thumb knuckle and over time that could get painful even without the "can't reach the controls easily" issues.
So, since I have large hands and little single stack / slim handgun experience, I thought I'd bring the question to the brain trust.