For those who don't know, I carry my P3AT more than anything else. My job and current carry options don't allow for anything bigger. Don't get me wrong, I feel completely under-gunned with the .380 and feel a lot more prepared carrying my .45 or 9mm, but like Slurpie said, a .380/.32/.25/.22 is better than nothing at all. I take that back, a pocket full of rocks would probably be better than a .25.
I'm thinking about trying Smart Carry, but don't know if I can comfortably carry (and effectively conceal) my XD9SC. There was an interesting video I saw on youtube of a guy who used Smart Carry to conceal a Glock 26. Here it is: http://www.youtube.com/watch?v=nkEfZUwzLAs