Do *not* use a flashlight with more than 300 lumens indoors. 220-250 would be best. Anything more than that, and you'll blind yourself just as badly as the bad guy if you hit the light when your eyes are fully adjusted to the dark.
Extremely bright lights are great for outdoors, and would make a great weapon light, perhaps a good outdoor carry light if its compact enough. If you want a light that can be used as an indoor/outdoor carry or nightstand light, stay away from the super bright ones.
As far as strobes go, unless you are on an entry team, or have the element of surprise on your side, you're never going to use it except to mess with your buddies. It's going to be hard enough simply holding and aiming your light if you need to should you ever find yourself in a lethal force encounter. Just make sure the light you choose can switch directly from on to off to on etc. without having to switch through strobe mode or it may goof you up.
I've got a drawer full of flashlights. These days I almost always carry a Streamlight ProTac 1L or ProTac 2L. The 2L fits in a back pocket perfectly, and the 1L fits nicely in a front pocket. They don't have a very aggressive strike bezel, but their bright enough, not too bright, fit in the hand nicely, and can be carried without a pouch and comfortable enough that you'll never even notice your wearing them.
http://www.streamlight.com/product/product.aspx?pid=200http://www.streamlight.com/product/product.aspx?pid=202You are now $0.02 richer.